Transcriptome analyses in aortic dissection and normal human aorta

To identify the m6A methylome in the aorta of patients with acute aortic dissection. MeRIP-seq and RNA-seq experiments of aortic media tissue samples obtained from AD patients and controls were conducted. Compared with control group, the upmethylated coding genes of AD were primarily enriched in the processes associated with extracellular fibril organization, while the genes with downmethylation were enriched in the processes associated with cell death regulation. Furthermore, many differentially methylated m6A sites (DMMSs) coding proteins were mainly annotated during the extracellular matrix and inflammatory responses. To identify the m6A methylome in the aorta of patients with acute aortic dissection.