MeRIP-seq of Alkbh5/Mettl3 knockout Bone marrow-derived macrophages

Alkbh5/Mettl3loxp/loxp mice were crossed with Lyz2-Cre mice to generate macrophage-specific conditional knockout mice for Alkbh5/Mettl3. Bone marrow-derived macrophages (BMDMs) were isolated from these mice, and MeRIP-seq was performed to investigate the impact of the knockout on RNA N6-Methyladenosine Bone marrow-derived macrophage from Mettl3loxp/loxp; Lyz2-Cre, Alkbh5loxp/loxp; Lyz2-Cre and WT