RNA-seq data for non-targeting siRNA and lncRNA LOL siRNA transfection in MCF-7 cells

To elucidate which portions of signaling pathways LOL influences in luminal breast cancer, RNA-seq analysis was performed in siLOL MCF-7 cell lines. Eight hundred eighty-three downregulated genes and 1182 upregulated genes (fold change ≥1.5) were detected after LOL knockdown. Gene set enrichment analysis (GSEA) of hallmarks indicated that the gene sets related to DNA_Repair, G2M_Checkpoint, E2F_Targets and MYC_Targets were positively correlated with LOL downregulation. Examine the gene expression pattern in NC and LOL KD MCF-7 cells, and compare the gene expression to find out the differentially expressed genes.