Fractalkine receptor CX3CR1 and leukocyte Ig-like receptor B2 LILRB2 are prognostic biomarkers in septic shock. Homo sapiens

Sepsis is a major health concern, with high morbidity and mortality workdwide. In order to identify prognostic biomarkers in septic shock patients, we performed a microarray study exploring the early modulation of gene expression according to day 28 mortality. Several candidate biomarkers including CX3CR1 and LILRB2 were identified as prognostic biomarkers. Overall design: 51 septic shock patients and 22 healthy volunteers were included in this study. Septic shock patients were sampled twice, at admission, and a second time at D2 or D3. Admission samples from septic shock patients were compared to healthy volunteers, and according to day 28 survival status. Modulation of gene expression between the 2 time points was also analyzed according to day 28 survival.