Additional file 1: Sheet 1. of A multi-factorial analysis of response to warfarin in a UK prospective cohort

Interaction coefficients of drugs known to be interacting with warfarin. Drugs known to interact with warfarin were classified according to their effect on warfarin dosing, with a plus sign for potentiating drugs, and minus for the opposite effect, the absolute value representing the scale of the effect. When several of these drugs were used concomitantly the sum of these coefficients was used. Sheet 2. List of all concomitant drugs taken by patients. Sheet 3. Top signals from linear regressions on SMWD. P values marked with an asterisk were obtained from the regression only adjusting for non-genetic factors, while other P values where obtained from a multiple regression after conditioning on rs9923231, rs1799853 and rs1057910. Sheet 4. Top signals from logistic regressions on INR >4 during first week of treatment. P values marked with an asterisk were obtained from the regression only adjusting for non-genetic factors, while other P values where obtained from a multiple regression after conditioning on rs2288004 and rs1072753. P values for rs9923231, CYP2C9 *2 and *3 are reported, albeit they were not the most statistically significant signals in their respective region. 95 % confidence intervals for odds ratios are indicated in parentheses. (XLSX 28 kb)