Association of genetic variants rs7759938 (upper panel) and rs314279 (lower panel) with adult metabolic profiles.

All phenotypes were standardized prior to analyses. Two regression models were used: Model A including age as a covariate, and Model B including both the alternative SNP and age as covariates. Subjects using lipid lowering drugs or with lipid levels +/−5 standard deviations (SD) from the mean were excluded from the lipid/lipoprotein analysis. Only subjects with normal glucose tolerance not receiving treatment for diabetes were included in the regression analyses of glucose and serum insulin. The effect allele for both rs7759938 and rs314279 is C. ApoA1 = Apolipoprotein A1, ApoB = Apolipoprotein B, FP = Fasting plasma. FS = Fasting serum, 2H glucose = Plasma glucose concentrations at 2 h after a 75 g oral glucose load. Participants of the oral glucose test were instructed to fast for 10 hours. # The variable was logarithm-transformed prior to the analysis.