Effect of intravenous administration of maropitant on blood pressure in healthy awake and anesthetized dogs

Objective: To evaluate the effects of intravenous maropitant
on arterial blood pressure in healthy dogs when awake and under general
anesthesia.

Design: Experimental crossover study

Animals: Eight healthy adult Beagle dogs.

Procedure: All dogs received maropitant 1 mg kg-1
intravenously during the following: awake with peripheral invasive blood
pressure (BP) (Awake), anesthetized groups with premedication with either
acepromazine 0.005 mg kg-1 and butorphanol 0.2 mg kg-1 (GaAB) or
dexmedetomidine 0.005 mg kg-1 and butorphanol 0.2 mg kg -1 (GaDB) followed by
general anesthesia with isoflurane.
Heart rate (HR), systolic (SAP), diastolic (DAP) and mean blood
pressures (MAP) were recorded before injection (baseline), during first 60
seconds of injection, during second 60 seconds of injection, at completion of
injection and every 2 minutes post injection for 18 minutes in each group. The data were compared over time using
Generalized Linear Model with mixed effects and then with simple effect
comparison with Bonferroni adjustments (p <0.05)

Edit log: the file "Research BP HR data individual dogs awake NIBP.csv" has been updated to correct the display of null values.