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RNA sequencing of blood monocyte subsets in COVID patients

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE176290
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We report mRNA expression profiles of blood monocyte subsets in COVID patients with comparison to non-COVD samples. COVID patients were grouped into mild without hospitalization and ICU without ventilation. Monocytes were FACS sorted based on CD14 and CD16 expression, generating classical CD14+CD16- monocytes and CD16+CD14+/++ nonclassical monocytes. The mRNA expression comparison demonstrates a strong response to viral infection and suggests a defect in nonclassical monocytes maturation. It also provides several biomarkers for prognosis purposes, including CD55 and CD81. Examination of mRNA expression profiles in blood monocyte subsets in COVID patients.
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2021-06-23
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