Activin A and BMP4 Modulation of Wnt/β-catenin Signaling Directs Fate Specification of Mesoderm Derivatives from Human Embryonic Stem Cells. Homo sapiens

We report the derivation of 2 different methods of generating cardiac myocytes from human ESCs. The traditional route is via cardiac progenitor cells and the second, new approach is through re-directing hemogenic endothelium into the cardiac lineage using inhibition of Wnt/b-catenin signaling Overall design: Examination of 2 different cardiac populations using RNA-seq