Overview of 25 simulated datasets generated by the AbSim R package [46].
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Each B cell clone is generated by one set of randomly selected unmutated human IGH-chain germline gene sequences [47] to produce the V(D)J recombination event. Then, the germline undergoes clonal expansion along a phylogenetic tree in which branching events occur stochastically. SHM along this tree is modeled using a local sequence context-dependent model (i.e., “S5F” model from [44]).
创建时间：
2020-06-23
