For each virus strain, PR8 and PR8-PB1-F2(1918), the MLE initial viral titer (), infection rate constant (), death rate of productively infected cells (), viral release rate per infected cell (), and
For in vivo studies of influenza dynamics where within-host measurements are fit with a mathematical model, infectivity assays (e.g. 50% tissue culture infectious dose; TCID50) are often used to estim
Like all biological populations, viral populations exist as networks of genotypes connected through mutation. Mapping the topology of these networks and quantifying population dynamics across them is