Hazard ratios for all-cause mortality derived in the Estonian Biobank cohort in the age range 25–74 y.

Hazard ratios for all-cause mortality derived in the Estonian Biobank cohort in the age range matching the FINRISK cohort (25–74 y). The regression coeffients (natural logarithm of the HRs) from the Estonian Biobank cohort were used to derive two risk scores for the prediction of all-cause mortality: a reference risk score without biomarkers and a risk score including the four novel biomarkers. The two risk prediction scores were used to calculate the absolute risk estimates in the FINRISK cohort, and the incremental predictive utility of adding the four biomarkers to the risk prediction score was evaluated.aContinuous variables were scaled to risk estimate per 1-SD increment in the variable.