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Loop Extrusion Mediates Physiological Locus Contraction for V(D)J Recombination. Loop Extrusion Mediates Physiological Locus Contraction for V(D)J Recombination

NIAID Data Ecosystem2026-03-11 收录

V(D)J重组

免疫基因座调控

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA637627 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

应用场景：

创建时间：

2020-06-05

V(D)J重组

淋巴细胞受体基因重组

A central unanswered question concerning the initial phases of V(D)J recombination has been at which step the 12/23 rule applies. This rule, which governs which variable (V), diversity (D), and joinin

PubMed Central70

NUDCD3 deficiency disrupts V(D)J recombination to cause SCID/Omenn syndrome

先天性免疫缺陷疾病

V(D)J重组

Inborn errors of T cell development present a pediatric emergency in which timely curative therapy is informed by molecular diagnosis. In 9 affected patients across 3 consanguineous kindreds, we detec

NIAID Data Ecosystem40

J region use by V14: comparison between experimental and simulation data.

V(D)J重组

*Frequencies of rearrangements of V14 genes were calculated from Figure 2 in Aude-Garcia et al.[10], for the combinations with three J panels, corresponding to series of J genes scattered along the J

NIAID Data Ecosystem30

Igk locus capture-based target enrichment sequencing. Igk locus capture-based target enrichment sequencing

V(D)J重组

DNA双链断裂修复

Cell cycle is a major determinant of DNA double-strand break (DSB) repair pathway choice with homologous recombination (HR) that is most active in S phase cells and non-homologous end-joining (NHEJ) t

NIAID Data Ecosystem50

CTCF-Binding Elements Mediate Accessibility of RAG Substrates During Chromatin Scanning [dataset 2]

V(D)J重组

染色质可及性调控

RAG endonuclease initiates antibody heavy chain variable region exon assembly from V, D, and J segments within a chromosomal V(D)J recombination center (RC) by cleaving between paired gene segments an

NIAID Data Ecosystem30

Loop Extrusion Mediates Physiological Locus Contraction for V(D)J Recombination. Loop Extrusion Mediates Physiological Locus Contraction for V(D)J Recombination

资源简介：

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