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Potent hiv protease inhibitors containing a novel (hydroxyethyl)amide isostere

NIAID Data Ecosystem2026-05-01 收录

HIV蛋白酶抑制剂

药物化学先导化合物

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https://www.rcsb.org/structure/1JLD 数据链接链接失效反馈

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Potent hiv protease inhibitors containing a novel (hydroxyethyl)amide isostere

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创建时间：

2024-02-07

有机合成方法

药物化学先导化合物

An approach to 1,3-disubstitued bicyclo[2.1.0]pentane (housane) derivatives was developed. The method relied on lithium bis(trimethylsilyl)amide-mediated intramolecular cyclization of trisubstitued

NIAID Data Ecosystem80

HIV-1 Protease (I84V) in Complex with LR3-68

HIV蛋白酶抑制剂

基于结构的药物设计

HIV-1 Protease (I84V) in Complex with LR3-68

NIAID Data Ecosystem30

HIV-1 wild type protease with a substituted bis-Tetrahydrofuran inhibitor, GRL-044-10A

HIV蛋白酶抑制剂

抗病毒药物设计

HIV-1 wild type protease with a substituted bis-Tetrahydrofuran inhibitor, GRL-044-10A

NIAID Data Ecosystem10

First Structure–Activity Relationship Study of Potent BLT2 Agonists as Potential Wound-Healing Promoters

药物化学先导化合物

伤口愈合促进剂开发

The first potent leukotriene B4 (LTB4) receptor type 2 (BLT2) agonists, endogenous 12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid (12-HHT), and synthetic CAY10583 (CAY) have been recently described t

NIAID Data Ecosystem40

Protease PR5-SQV

HIV蛋白酶抑制剂

抗病毒药物设计

Protease PR5-SQV Descriptor: (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)b

Protein Data Bank Japan2024-03-06 更新30

Potent hiv protease inhibitors containing a novel (hydroxyethyl)amide isostere

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