RNA alterations induced by influenza infection

The H13N2 subtype avian influenza virus (AIV) is a virus with cross-species transmission capability, which was previously known to mainly infect waterfowl. However, recent studies have confirmed that this virus can also infect poultry and mammals. This cross-species transmission ability has raised widespread concerns about its potential public health threat. In this study, we used the human lung epithelial cell line A549 as a model to investigate the changes in RNA expression after 24 hours of infection with H13N2 virus. These findings provide important insights into the cross-species transmission mechanism of H13N2 virus and its impact on host cells, while also offering a scientific basis for assessing its potential public health risks and developing prevention strategies. Overall design: RNA-seq were performed for A549 cell lines with or without H1N1 or H13N2 infection