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Lysosomal catabolic activity governs the exit of the murine totipotent 2-cell state by silencing early-embryonic retrotransposons

NIAID Data Ecosystem2026-05-02 收录

早期胚胎发育

植物逆转录转座子调控

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE247083 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2024-11-24

类囊胚模型构建

早期胚胎发育

Human blastocysts are comprised of the first three cell lineages of the embryo: trophectoderm, epiblast, and primitive endoderm, all of which are essential for early development and organ formation1,2

NIAID Data Ecosystem60

Mediator complex component MED13 regulates zygotic genome activation and is required for postimplantation development

合子基因组激活

早期胚胎发育

Understanding the factors that regulate the transition from oocyte to embryo is critical for determining how cells are reprogrammed to become totipotent or pluripotent. Although factors that can repro

NIAID Data Ecosystem30

Genome-wide analysis of early mouse development

早期胚胎发育

基因表达调控

Throughout the course of early development, the reliable occurrence of stereotyped events is imperative. This careful orchestration is dependent upon regulation at the level of gene expression. While

Alliance of Genome Resources30

Antisense c-myc effects on preimplantation mouse embryo development.

早期胚胎发育

反义基因功能研究

Antisense DNA inhibition of gene expression was explored as an approach toward elucidating mechanisms regulating development of preimplantation mammalian embryos. Specifically, a role for the c-myc pr

PubMed Central1992-11-01 更新50

Overlapping roles and requirement of histone deacetylase 1 and 2 in lineage development and genome-wide DNA methylation during mouse preimplantation development

早期胚胎发育

组蛋白去乙酰化酶

Epigenetic modifications, including DNA methylation and histone modifications, are reprogrammed considerably following fertilization during mammalian early embryonic development. Incomplete epigenetic

NIAID Data Ecosystem30

Lysosomal catabolic activity governs the exit of the murine totipotent 2-cell state by silencing early-embryonic retrotransposons

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