Power for 2000 trios and 500K markers, using mating type ratio equation R4, under an “unknown” genetic model.

Estimated power levels to detect the DSL using 2000 trios, assuming a 10% disease prevalence. The significance level is set to 5%. For the weighted Bonferroni method (Weighted), the partitioning parameters are K = 7 and r = 2. “Under True Gen. Model”, Add. refers to the scenario where the true (but “unknown”) model is additive (as the results are analyzed using all three genetic models). Similar scenarios are provided for the dominant (Dom.) and recessive (Rec.) genetic models. MAF denotes minor allele frequency. The power reflects the proportion of times the p-value of the DSL (Independence scenario and LD scenario (DSL only)) or a SNP in LD with the DSL (LD scenario (DSL+)) met the weighted Bonferroni (Weighted) or standard Bonferroni corrected (Standard) significance level. The standard Bonferroni correction adjusts for 1.5 M comparisons (500 K markers * 3 genetic models).