LC-MS proteomics analysis of the insulin/IGF-1-deficient Caenorhabditis elegans daf-2(e1370) mutant reveals extensive restructuring of intermediary metabolism.

Data from ProteomeXchange, PXD ID: PXD002161. File: c_elegans_A_3_8_21Apr10_Draco_10-03-04.mzml. Published as part of J Proteome Res. 2014 Apr 4;13(4):1938-56 . From the Abstract: {{i}} ... Taking advantage of the recent developments in quantitative liquid chromatography mass spectrometry (LC-MS)-based proteomics, we profiled the proteomic changes that occur in response to activation of the DAF-16 transcription factor in the germline-less glp-4(bn2);daf-2(e1370) receptor mutant. Strikingly, the daf-2 profile suggests extensive reorganization of intermediary metabolism, characterized by the upregulation of many core intermediary metabolic pathways ... {{/i}}