KIT kinase domain in complex with a 7-methoxyquinazolin-6-ol-based compound (45)

KIT kinase domain in complex with a 7-methoxyquinazolin-6-ol-based compound (45) Descriptor: 4-[4-[5-[(1~{S})-1-azanyl-1-(4-fluorophenyl)ethyl]pyrimidin-2-yl]piperazin-1-yl]-7-methoxy-quinazolin-6-ol, Mast/stem cell growth factor receptor Kit Authors: Scrima, A, Mueller, M.P, Rauh, D. Deposit date: 2025-11-27 Release date: 2026-07-15 Last modified: 2026-08-19 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structure-based scaffold hopping reveals strategies to overcome oncogenic KIT and PDGFRA mutation-driven drug-resistance in GIST. Nat Commun, 17, 2026