DNA methylation and gestational diabetes mellitus. DNA methylation and gestational diabetes mellitus

Gestational diabetes mellitus is associated with DNA methylation and lifestyle. The effects of DNA methylation on GDM, and interaction between DNA methylation and lifestyle factors are not well elucidated. The objective of this study was to explore the association between GDM, DNA methylation and lifestyle factors. A nest case-control design was performed. Sociodemographic data, dietary intake and daily physical activity information of participants were collected. Bisulfate pyrosequencing was used to detected the DNA methylation level of PPARGC1A, HLA-DQA1 and ADCY3 genes. The differences of DNA methylation levels between GDM group and control group were compared. The correlation between clinical characteristics, dietary, physical activity and the DNA methylation level were analyzed.