Bruton's tyrosine kinase in complex with compound 65
收藏Protein Data Bank Japan2023-10-18 更新2026-04-19 收录
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Bruton's tyrosine kinase in complex with compound 65 Descriptor: (3R,3'R)-3-anilino-1'-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)[1,3'-bipiperidin]-2-one, Tyrosine-protein kinase BTK Authors: Metrick, C.M, Marcotte, D.J. Deposit date: 2021-06-04 Release date: 2022-05-18 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton's tyrosine kinase inhibitors. Bioorg.Med.Chem., 44, 2021
创建时间：
2021-06-04
