GRN haploinsufficiency causes frontotemporal lobar degeneration and results in microglial hyperactivation, lysosomal dysfunction and TDP-43 deposition. To understand the contribution of microglial hyp
BV2 cells were treated with α-M or NP-α-M, and the total RNA was extracted using Trizol (ThermoFisher). RNA analysis was conducted by Shanghai Personalbio Technology Co., Ltd, China. The sequencing l
Alzheimer's disease (AD) is a detrimental neurodegenerative disease with no effective treatments. Due to cellular heterogeneity, the roles of immune cell subsets in AD onset and progression are poorly
