Single-nucleus RNA-Seq of enteric neurons of adult mice, derived from the major regions of the intestine. Myenteric neurons were isolated from the duodenum, ileum, and colon of adult Phox2b-CFP mice (
We uncovered orderly genetic tiers that sequentially divide groups of neurons by their motor- sensory, local-long range, and excitatory-inhibitory features. The genetic signatures defining neuronal pr
Mutations in Cu/Zn superoxide dismutase 1 (SOD1) lead to Amyotrophic Lateral Sclerosis (ALS), a neurodegenerative disease that disproportionately affects glutamatergic and cholinergic motor neurons. P
