In vivo evaluation of thermally drawn biodegradable optical fibers as brain implants

Dataset for Thermal, Molecular, and Optical Characterization of PDLLA Optical Fibers

Parinaz Abdollahiana,b, Kunyang Suia,b, Guanghui Lib, Jiachen Wanga, Cuiling Zhanga, Yazhou Wanga, Rune W. Bergb, Marcello Meneghettia,b, and Christos Markos*a

a. Department of Photonics and Electronic Engineering, Denmark Technical University, Denmark

b. Department of Neuroscience, Copenhagen University, Copenhagen, Denmark

Description:This dataset includes the experimental data and characterization results for amorphous poly(D,L-lactic acid) (PDLLA) optical fibers used in the study titled "In vivo evaluation of thermally drawn biodegradable optical fibers as brain implants." The dataset comprises the following key measurements:

Differential Scanning Calorimetry (DSC):

Thermograms of PDLLA granules as purchased and after quenching, used to analyze thermal transitions.

Gel Permeation Chromatography (GPC):

Molecular weight data of PDLLA before and after in vivo degradation.

Optical Transmission:

Spectral data for PDLLA fibers of different diameters (150 µm, 250 µm, and 320 µm) and their transmission properties before and after in vitro degradation in phosphate-buffered saline (PBS).

Purpose:The data support the evaluation of the thermal stability, molecular degradation, and optical performance of PDLLA fibers under in vitro and in vivo conditions. The goal is to assess their suitability as biodegradable neural interfaces for biomedical applications.

Methods:

DSC was performed on a Q 2000 instrument with a temperature range of -10°C to 200°C at a heating rate of 10°C/min and a cooling rate of 50°C/min.

GPC was conducted using a TOSOH HLC-8320 to measure molecular weight distributions.

Optical transmission was characterized using a broadband supercontinuum source (NKT SuperK Extreme) and an ANDO AQ-6315A optical spectrum analyzer.

File Contents:

DSC raw and processed data for granules and quenched PDLLA.

GPC chromatograms and molecular weight calculations.

Transmission spectra for PDLLA fibers, including pre- and post-degradation measurements.