Biemamides A–E, Inhibitors of the TGF‑β Pathway That Block the Epithelial to Mesenchymal Transition
收藏NIAID Data Ecosystem2026-03-10 收录
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Screening of a marine natural products library for inhibitors of TGF-β revealed five pyrimidinedione derivatives, biemamides A–E (1–5). The structures were determined by 2D NMR and HRMS experiments; absolute configurations were established by advanced Marfey’s analysis and ECD calculations. Biemamides A–E specifically inhibited in vitro TGF-β induced epithelial to mesenchymal transition in NMuMG cells. Additionally, using Caenorhabditis elegans, selected biemmamides were found to influence in vivo developmental processes related to body size regulation in a dose-dependent manner.
创建时间：
2018-08-30
