Processed spatial transcriptomic and single-cell RNA-seq objects and analysis code for "Spatial multiomics uncovers an SPP1+ macrophage-driven anti-apoptotic niche in osteoarthritis synovium via the SPP1-CD44 axis"

This record contains processed RDS/Seurat objects and R scripts supporting the analyses in the associated manuscript, “Spatial multiomics uncovers an SPP1+ macrophage-driven anti-apoptotic niche in osteoarthritis synovium via the SPP1-CD44 axis”. Files include processed spatial transcriptomic and macrophage analysis objects, the SPP1 virtual knockout result object, and R scripts for downstream GO, GSEA, and KEGG enrichment analyses. Raw spatial transcriptomic and RAW264.7 RNA-seq data have been deposited in CNGBdb [temporary accession/link]. The files in this Zenodo record are restricted during peer review and will be made publicly available upon acceptance of the associated manuscript.