Dent2: Caries in Permanent Dentition

[**Link to project pages of Dent2: Caries in Permanent Dentition**](http://www.facebase.org/hgai/DENT2.html) dbGaP Study Accession: [phs000095.v3.p1](https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000095.v3.p1) Principal Investigator: [Mary Marazita](https://www.dental.pitt.edu/person/mary-l-marazita), University of Pittsburgh School of Dental Medicine, Pittsburgh, PA, USA Funding Sources: U01-DE018903, Dental Caries: Whole Genome Association and Gene x Environment Studies. National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA R01-DE014899, Factors contributing to oral health disparities in Appalachia. National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA R03-DE021425, Statistical Modeling and Genetic Epidemiology of Dental Caries in GWAS Analysis, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA R01-DE09551, Longitudinal study of fluoride, diet, caries, and fluorosis. National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA R01-DE12101, Fluoride and other factors in childhood and adolescent bone development. National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA Dental caries is one of the most common diseases worldwide. In the US, the prevalence in adults is approximately 90% (Beltran-Aguilar et al., 2005), and in some high-risk populations, the prevalence is even higher. Treatment of dental caries consumes significant resources each year, and untreated caries lesions can lead to pain, tooth loss, and oral infection, or other co-morbidities. Cariogenesis is affected my numerous environmental, behavioral, and genetic factors, including dietary behaviors, bacterial flora, fluoride exposure, salivary factors, tooth morphology, etc. (Hunter, 1988; Anderson, 2002). This study of dental caries focuses on caries in permanent dentition in adults. Five independent samples were included from the Center for Oral Health Research in Appalachia (COHRA), the University of Pittsburgh School of Dental Medicine Dental Registry and DNA Repository (DRDR1, DRDR2), the Atherosclerosis Risk in Communities (ARIC) Study, and the Health Professionals Follow-up Study (HPFS). Detailed information of each study can be found in in Wang et al. [[Genome-wide association scan of dental caries in the permanent dentition](https://www.ncbi.nlm.nih.gov/pubmed/23259602), BMC Oral Health 12:57, 2012]. Click [here](/hgai/DENT2.html) to access the data and results for this dataset.