MOESM6 of Cellular and molecular characterization of multiplex autism in human induced pluripotent stem cell-derived neurons

Additional file 6: Table S5. (A) Clusters of co-expressed DEGs in cExN and cIN NPCs, with (B-G) associated ToppGene GO-, disease-, and pathway-associated terms. (H-I) DEGs associated with ASD. DEGs specific to the AP (Fig. 5A, E) and DEGs with similar expression in the AP and IS that differed from expression in the UM +/− UC (Fig. 4a, e) were visualized by hierarchical clustering in Fig. 6 and were compared with ASD-associated genes in the SFARI gene database [43], with the Geisinger Developmental Brain Disorder Genes Database [44], and with adult-onset psychiatric disorder-associated genes from PsyGeNET [45, 46]. RPKM values for each gene and sample are shown. The SFARI gene database indicates how each gene is associated with ASD (genetic category, gene score, and number of reports). The Geisinger database indicates the pattern of inheritance of mutations in each gene and the number of reports linking each gene to intellectual disability (ID), ASD, epilepsy (EP), attention-deficit/hyperactivity disorder (ADHD), schizophrenia (SCZ), or bipolar disorder (BD). The PsyGeNET database indicates genes associated with the disorders shown, with ‘unique 4 or 5 abstract’ indicating higher confidence associations.