Table_2_The Role of Gut Microbiota in Neuropsychiatric Diseases – Creation of An Atlas-Based on Quantified Evidence.docx

There is a growing body of evidence highlighting the significant role of gut microbiota in various pathologies. We performed a systematic review to review the different microbiota involved in neuropsychiatric diseases. 50 studies (23 studies for autism spectrum disorders, 18 for major depression, and 9 for schizophrenia), representing 2,137 patients and 2,844 controls. Concerning the microbiota, the genera Prevotella, Clostridium, Bacteroides, Bifidobacterium, Ruminococcus, Megamonas, and Faecalbacterium were the ones detected with the most frequent variation of their relatives abundance. We also assess the overlap between the different pathologies. This study provides new insights into the complex relationship between the brain and the gut and the implications in neuropsychiatric pathologies. The identification of unique signatures in neuropsychiatric diseases suggests new possibilities in targeted anti or probiotic treatment.

日益增多的研究证据突显了肠道微生物群在多种病理状态中的重要作用。本研究对涉及神经精神疾病的微生物群进行了系统综述。共纳入50项研究（其中23项针对自闭症谱系障碍，18项针对重度抑郁症，9项针对精神分裂症），涉及患者2,137例及对照者2,844例。在微生物群方面，普雷沃菌属、梭菌属、拟杆菌属、双歧杆菌属、瘤胃球菌属、巨单胞菌属和粪肠球菌属是检测到其相对丰度变化最为显著的菌属。同时，我们还评估了不同病理状态之间的重叠。本研究为大脑与肠道之间复杂关系的理解提供了新的洞见，并探讨了其在神经精神病理学中的影响。神经精神疾病中独特标志物的识别为靶向抗或益生菌治疗提供了新的可能性。