RNA-seq transcriptonal profiling in neonatal rat ventricular myocytes under hypertrophic growth. RNA-seq transcriptonal profiling in neonatal rat ventricular myocytes under hypertrophic growth

Heart failure is a leading cause of death in US. Hypertension is one of the most important risk factor of heart failure. In the presence of high blood pressure, the heart manifests hypertrophic growth to ameliorate ventricular wall stress. This once adaptive response may progress into decompensation and heart failure. The precise mechanisms governing this transition remain elusive. Here, we aimed to identify novel signaling pathways in cardiac hypertrophic growth. Primary neonatal rat ventricular myocytes (NRVMs) were isolated from 1-2 days old rats and treated with phenylephrine or IGF-1. Total RNA was isolated for RNA-seq analysis. Overall design: Transcriptional profiling in in neonatal rat ventricular myocytes under hypertrophic growth by RNA-seq analysis.