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Pluripotent Stem Cells Induced from Mouse Neural Stem Cells and Small Intestinal Epithelial Cells by Small Molecule Compounds

ChEBI2016-07-03 更新2026-07-12 收录

干细胞重编程

化学诱导多能性

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-75522 数据链接链接失效反馈

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Pluripotent Stem Cells Induced from Mouse Neural Stem Cells and Small Intestinal Epithelial Cells by Small Molecule Compounds

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创建时间：

2016-07-03

干细胞重编程

早期胚胎发育

IL-6 has been shown to be required for somatic cell reprogramming into induced pluripotent stem cells (iPSCs). However, how the cytokine is regulated and if it plays a role during embryo development r

NIAID Data Ecosystem50

Chromatin Accessibility Dynamics during Chemical Induction of Pluripotency [RNA-seq]. Chromatin Accessibility Dynamics during Chemical Induction of Pluripotency [RNA-seq]

干细胞重编程

染色质可及性调控

Chemical induction of pluripotency (CIP) is an ideal way to reprogram cell fate, but remains poorly understood. Here we report the development of an efficient CIP protocol and the chromatin accessibil

NIAID Data Ecosystem40

Additional file 6: of Sirt6 regulates efficiency of mouse somatic reprogramming and maintenance of pluripotency

干细胞重编程

表观遗传调控

Table S2. Gene ontology analysis from downregulated gene sets in Sirt6-null iPS-like cells. (XLSX 41 kb)

Figshare2024-02-14 更新30

Transcription factor NKX3-1 is required for reprogramming to pluripotency and can replace OCT4 in mouse and human iPSC induction [ATAC-seq]. Homo sapiens

干细胞重编程

转录因子功能

Resolution of early molecular events preceding endogenous OCT4 activation is critical to understanding the mechanism of reprogramming somatic cells to induced pluripotent stem cells (iPSCs), yet captu

NIAID Data Ecosystem40

α-Ketoglutarate inhibits the pluripotent-to-totipotent state transition

干细胞重编程

代谢调控机制

In early mouse embryogenesis, the distinct enrichment of α-ketoglutarate (αKG) in blastocysts and L-2-hydroxyglutarate (L-2HG) in 2-cell (2C) embryos serves as a key metabolic signature. While elevate

NIAID Data Ecosystem30

Pluripotent Stem Cells Induced from Mouse Neural Stem Cells and Small Intestinal Epithelial Cells by Small Molecule Compounds

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