Summary statistics for genes with significant differential dose-expression relationship based on qRT-PCR measurements.

1CNV, Copy number variation as reported in Stein et al. with either amplified regions or not (no) is shown for each cytoband where our candidate genes are located.2Number of paired (tumor/normal tissue) observations.3Columns with subtitles 1 and 2 refer to dose categories (1 and 2) and reflect the fold change in differential gene expression for a specific dose category relative to the referent dose category (0). Fold change in expression associated with dose were computed as two to the power of the difference in the slopes, i.e. 2ˆ(dosetumor−dosenormal).4Two degree of freedom test in differential dose-response.5One degree of freedom trend test in differential dose-response.6All models of differential dose-response were adjusted for tissue type, attained age, sex, and oblast of residence.