Base-Mediated Tunable Synthesis of 2‑Trifluoromethylated Furans and Dihydrofuranols: Extraordinary Stable in Sulfuric Acid
收藏NIAID Data Ecosystem2026-03-11 收录
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2-Trifluoromethylated furans and dihydrofuranols were tunably synthesized from the cyclization of β-ketonitriles with 3-bromo-1,1,1-trifluoroacetone mediated by bases. In addition, dehydration of dihydrofuranol compounds with concentrated sulfuric acid gave another 2-(trifluoromethyl)furans isomer. The developed methodology exhibits an excellent functional group tolerance for both aromatic and aliphatic β-ketonitriles.
创建时间：
2019-11-07
