ICER values (€) at the variation of each single base case parameter (min, max) under the three discount scenarios.

ICER values (€) at the variation of each single base case parameter (min, max) under the three discount scenarios (Scenario 1: 3.% discount rate for both costs and benefits, Scenario 2: 1.5% discount rate for both costs and benefits, Scenario 3: no discounting).a Lower and upper bound of the disease incidence and the case fatality rate was calculated using the minimum and maximum value for each age class over the 6-year study period.b Lower and upper bound was equal to +/- 20% of the base case value.c Lower and upper bound of hospital costs was calculated using the minimum and maximum value acquired from the Italian Hospital Discharge Database.d Cost of follow-up for survivals both with and without sequelae was obtained using estimates from an Italian study by Lucioni [46].e Examples for some of the main sequelae.f Lower bound was drawn based on the estimate of the Italian strain coverage using the MATS assay (87%) [13].ICER values (€) at the variation of each single base case parameter (min, max) under the three discount scenarios.