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Identification of unique cell type responses in pancreatic islets to stress

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NIAID Data Ecosystem2026-05-02 收录
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We single cell sequenced multiplexed primary human islets treated ex vivo with ER and inflammatory chemicals, indexed cell type specific stress responses, found genes to regulate in SC-islets to reduce apoptosis. We conducted multiomic ATAC+RNA sequencing on human islets treated with BFA, DMSO, IL1B+IFNG+TNFa, or PBS Overall design: Single cell RNA sequencing of primary human islets treated with Brefeldin A, Thapsigargin, and a variety of cytokines

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2024-08-02
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