T cell receptor and co-stimulatory signaling

The activation and translocation of transcription factors NFAT, AP-1 and NF-kappa-B via the co-stimulatory signaling cascade triggered by MHC peptide, B7 proteins and PD-L1. The activation of NFAT involves a Ca2+/calcineurin disruption of a massive RNA-protein complex prior to its translocation into the nucleus and ultimate transcription factor activity.

通过由MHC肽、B7蛋白和PD-L1触发的协同刺激信号级联，激活并转位转录因子NFAT、AP-1和NF-kappa-B。NFAT的激活过程涉及钙离子/钙调神经磷酸酶破坏大量RNA-蛋白复合物，在此复合物转位至细胞核并最终发挥转录因子功能之前。