Supplementary Material for: Efficacy of siltuximab and 1927 nm fractional laser for the treatment of cutaneous manifestations in Castelman’s disease: the role of dermoscopy and reflectance confocal microscopy for lesion evaluation

Introduction. Multicentric Castelman’s disease (MCD) with cutaneous involvement has rarely been discussed in dermatologic literature, with few reports. Cutaneous lesions in MCD may induce deep scars, causing a significant impact in the daily life of the patients. The treatment of Castelamn’s disease (CD) is usually a challenge, especially in case of cutaneous involvement. Case presentation. We report the case of a 35-year-old Caucasian man with a 3-year-old history of MCD with cutaneous involvement, that we treated with a combined therapy characterized by siltuximab and 1927 nm fractional laser. The patient showed a therapeutic response, characterized by a reduction of systemic symptoms and cutaneous manifestations. Conclusion. We believe that the combination of siltuximab and 1927 nm fractional laser might have a synergistic beneficial role in patients with cutaneous iMCD, and maximize aesthetic outcomes. Anyway, additional evidence is needed to validate our findings.