Clinical and viral characteristics of HIV-1 infected children(a).

(a)symbol - means that the event has not occurred. n.a. = not available. Mos means months of age. Age of appearance of the different conditions is always indicated in months.(b)Narrow and broad refer to viruses with R5 phenotype. Viruses able to exclusively use wild type CCR5 receptor are defined narrow, whereas those using chimeric receptors besides the wild type CCR5 are defined broad. In parenthesis is indicated the age in months of the virus phenotype determination.Statistical analysis: Influence of virus R5broad phenotype on disease progression including children of group 1 and 2, or children of group 1, 2 and 3: p = 0.0260 and p = 0.0218 (Pearson's chi Square), respectively.(c)Age of entry into clinical or immunological category. Categories are defined according to the Centers for Disease Controls [21]: CDC 3 = severe immune suppression; CDC B = moderate clinical manifestations; CDC C = severe clinical manifestations.(d)Age of start of mono or dual antiretroviral therapy, not HAART.