Role of RNA m6A Methylation in Regulating Alzheimers Disease (PRJCA018680)

Previous studies have shown that m6A methylation plays a key role in neural development and the maintenance of physiological functions of the nervous system. Disorders in m6A methylation are closely related to neuronal functional defects, suggesting that m6A modification has a potential regulatory role in the pathogenesis of AD. In this study, we used the AD mouse model and the AD brain organoid model to explore the potential role of m6A in regulating AD pathogenesis through integrated analysis of transcriptome and m6A methylation sequencing data.