Donor specific transcriptomic analysis of Alzheimer's disease associated hypometabolism highlights a unique donor, microglia, and ribosomal proteins

Supplement data and figures from "Donor specific transcriptomic analysis of Alzheimer's disease associated hypometabolism highlights a unique donor, microglia, and ribosomal proteins"Preprint:https://www.biorxiv.org/content/10.1101/2019.12.23.887364v4Github:https://github.com/leonfrench/AD-Allen-FDGExtended Data Figure 1-1: Details of the FDG-PET studies used in the meta-analysis.Extended Data Table 1-1: Complete GO enrichment results for all donors separately.Extended Data Figure 3-1: Complete GO enrichment results for step-wise increases across DAM clusters.Extended Data Figure 3-2: Complete GO enrichment results for step-wise increases across the human AD pathology subgroups.Extended Data Figure 3-3: ER translocation gene step-wise results for other cell-types across the human AD pathology subgroups.Supplement Figure 1: Differential expression of ER translocation genes in microglia from individuals with Alzheimer’s disease. In the top row, ROC curves show the proportion of ER translocation genes (y-axis, true positive fraction) across the genes tested for differential expression in microglia. The tested genes were ranked from the most overexpressed in early-pathology compared to no-pathology (A) and overexpressed in late-pathology compared to early-pathology (B). Subpanels C and D show the corresponding distributions with a black lines marking ER translocation genes across the differential expression rankings.