Carrez et al 2025 Figure S1 to S7

NIAID Data Ecosystem2026-05-02 收录

囊性纤维化治疗机制

药物疗效细胞模型

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https://figshare.com/articles/dataset/Carrez_et_al_2025_Figure_S1_to_S7/29402219 数据链接链接失效反馈

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资源简介：

We studied the cellular and molecular mechanisms underlying Trikafta's clinical efficacy, by using human bronchial epithelial cells from F508del homozygous patients and human bronchial epithelial CFBE41o- cells expressing F508del-CFTR.

创建时间：

2025-06-25

Neutrophil Elastase Enhances Sputum Solubilization in Cystic Fibrosis Patients Receiving DNase Therapy

囊性纤维化治疗机制

痰液溶解酶学

Cystic fibrosis patients suffer from chronic lung infection and inflammation due to the secretion of viscous sputum. Sputum viscosity is caused by extracellular DNA, some of which originates from the

NIAID Data Ecosystem50

γ-glutamylcysteine (GGC) supplementation and p-LPS challenge causes distinct proteomic changes to primary airway epithelial cell models of Cystic Fibrosis

囊性纤维化治疗机制

蛋白质组研究

Cystic fibrosis (CF) is a life limiting inherited condition associated with recurrent bacterial infections, inflammation, oxidative stress and loss of lung function. CF is characterised by deficiencie

NIAID Data Ecosystem10

Target Identification with Live-Cell Photoaffinity Labeling and Mechanism of Action Elucidation of ARN23765, a Highly Potent CFTR Corrector

药物靶点识别

囊性纤维化治疗机制

Molecular-targeted therapies for the treatment of cystic fibrosis (CF) rely on small-molecule modulators that rescue the activity of the defective CF transmembrane conductance regulator (CFTR) anion c

NIAID Data Ecosystem00

Neutrophil Elastase Enhances Sputum Solubilization in Cystic Fibrosis Patients Receiving DNase Therapy

囊性纤维化治疗机制

痰液溶解分子病理

Cystic fibrosis patients suffer from chronic lung infection and inflammation due to the secretion of viscous sputum. Sputum viscosity is caused by extracellular DNA, some of which originates from the

Figshare2016-01-18 更新10

Restoration of Cellular Homeostasis by Vx-445 Under ER Stress Conditions: Insights from Biochemical and Proteomic Assays _ Expression Proteomics_1

囊性纤维化治疗机制

应激蛋白质组学

Endoplasmic reticulum (ER) stress is a patho-physiological condition that plays a central role in the development of various human diseases. Multiple intracellular and extracellular factors can impair

NIAID Data Ecosystem10

Carrez et al 2025 Figure S1 to S7

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