Subtelomeric p53 Binding Prevents Accumulation of DNA Damage at Human Telomeres

ChEBI2016-01-07 更新2026-07-12 收录

DNA损伤保护

p53蛋白功能

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Subtelomeric p53 Binding Prevents Accumulation of DNA Damage at Human Telomeres

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2016-01-07

Hibiscus acetosella extract protects against alkylating agent-induced DNA damage in mice

植物提取物

DNA损伤保护

Abstract Hibiscus acetosella was shown to exert beneficial effects in humans and animal models however, the effects of this plant on DNA are unknown. The aim of this study was to determine the antigen

DataCite Commons2020-08-28 更新60

p53 dimers elicit unique tumor suppressive activities through an altered metabolic program [scRNA-seq]

癌细胞重编程

p53蛋白功能

Cancer-related alterations of the p53 Tetramerization Domain (TD) abrogate wild-type (WT) p53 function. They result in a protein that preferentially forms monomers or dimers. These are also normal p53

NIAID Data Ecosystem50

Change of the Death Pathway in Senescent Human Fibroblasts in Response to DNA Damage Is Caused by an Inability To Stabilize p53

细胞衰老机制

p53蛋白功能

The cellular function of p53 is complex. It is well known that p53 plays a key role in cellular response to DNA damage. Moreover, p53 was implicated in cellular senescence, and it was demonstrated tha

PubMed Central30

Targeted citrullination enables p53 binding to non-canonical sites

p53蛋白功能

蛋白质翻译后修饰

TP53 encodes for the transcription factor p53, which binds to a diverse set of target genes in response to stress. Activation of p53 results in highly specific transcriptional responses, but the regul

Mendeley Data50

Subtelomeric p53 Binding Prevents Accumulation of DNA Damage at Human Telomeres. Homo sapiens

DNA损伤保护

p53肿瘤抑制机制

Telomeres and tumor suppressor protein TP53 (p53) function in genome protection, but a direct role of p53 at telomeres has not yet been described. Here, we have identified non-canonical p53 binding si

NIAID Data Ecosystem40

Subtelomeric p53 Binding Prevents Accumulation of DNA Damage at Human Telomeres

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