Molecular alterations in recurrent microdissected gliomas.

*Tumor not suitable for microdissection.**Oligodendroglioma with discernible tumor component of predominantly astrocytic morphology.Surgery: designates the individual center of tumor operation:B: Charité Universitätsmedizin, Berlin, Germany.#: number of all tumors analyzed.n (P): number of individual tumor pairs.P/R: identifies primary (P) and recurrent (R) tumor of each tumor pair.ID: internal tumor ID.Tissue: abbreviation of diagnosis based on histology.het.: retained heterozygosity.LOH: loss of heterozygosity.wt: wild type TP53/IDH1.Figure: Figure illustrating respective molecular data. Bold characters:n (P): highlight every second tumor pair of individual patients.P/R: highlight every primary tumor of individual patients.In all remaining columns bold characters highlight tumor pairs with heterogeneous distinct molecular alterations in their respective astrocytic and oligodendroglial tumor component. Italic characters:Highlight tumor pairs with novel molecular alterations during tumor progression. Bold italic characters:Highlight tumor pairs in which molecular alterations of the primary tumor are lost during tumor progression.