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In Vivo RNA Interference Screening Identifies a Leukemia-Specific Dependence on Integrin Beta 3 Signaling

ChEBI2013-04-24 更新2026-07-21 收录

白血病靶点筛选

整合素信号通路

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-46302 数据链接链接失效反馈

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In Vivo RNA Interference Screening Identifies a Leukemia-Specific Dependence on Integrin Beta 3 Signaling

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2013-04-24

阿尔茨海默病机制

整合素信号通路

αν and β1 integrins mediate Aβ–induced neurotoxicity in primary hippocampal neurons. We treated hippocampal neurons with 2.5 µg/mL 17E6 and 5 µg/mL ab58524, which are specific αν and β1 integrin antag

NIAID Data Ecosystem60

Alpha 5 Integrin Mediates Osteoarthritic Changes in Mouse Knee Joints

关节炎机制研究

整合素信号通路

Osteoarthritis (OA) is one of most common skeletal disorders and can affect synovial joints such as knee and ankle joints. α5 integrin, a major fibronectin receptor, is expressed in articular cartilag

NIAID Data Ecosystem40

Two Distinct Integrin-Mediated Mechanisms Contribute to Apical Lumen Formation in Epithelial Cells

上皮细胞调控

整合素信号通路

BackgroundFormation of apical compartments underlies the morphogenesis of most epithelial organs during development. The extracellular matrix (ECM), particularly the basement membrane (BM), plays an i

Figshare2016-01-18 更新10

Gene expression profiling of tumor cells and M2 macrophages from WT mice and mice with deletion of integrin beta3 in macrophage lineage cells (b3KOM)

肿瘤微环境

整合素信号通路

To better understand the impact of integrin beta3 signaling in myeloid cells on the tumor microenvironment, we compared the gene expression profiles of FACS isolated GFP+ PyMT-BO1 MFP tumor cells and

NIAID Data Ecosystem50

shRNA Screening Identifies JMJD1C as being required for Leukemia Maintenance (Agilent). Mus musculus

白血病靶点筛选

癌症表观遗传学

We used a mouse model of human AML induced by the MLL-AF9 fusion oncogene, and an epigenetic shRNA library to screen for novel potential drug targets. One of the best candidate drug targets identified

NIAID Data Ecosystem20

In Vivo RNA Interference Screening Identifies a Leukemia-Specific Dependence on Integrin Beta 3 Signaling

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