scRNAseq and scTCRseq data from tumor-infiltrating lymphocytes
收藏NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE298152
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资源简介：
In cancer models, CD103+CD8 TRM cells are implicated in the response to anti-PD-1 immunotherapy, and a subset of CD4 TRM cells expressing the integrin CD49a is required for response to anti-CTLA-4 immunotherapy. We performed single-cell RNA sequencing on tumour-infiltrating T lymphocytes (TILs) isolated from colon carcinoma et unsupervised analyses reveal several TRM populations. SCRNAseq and TCRseq are performed using 10X genomics technology on lymphocytes from tumor of 8 mice (4 different conditions and 2 replicates per condition): - ISO : isotype sample_1 - ISO_dup :isotype sample_2 aPD1 : sample anti-PD1_1 aPD1_dup :sample anti-PD1_2 aCTLA4: sample anti-CTLA4_1 aCTLA4_dup :sample anti-CTLA4_2 combo : sample_anti-PD1_anti-CTLA4_1 combo_dup : sample_anti-PD1_anti-CTLA4₂
创建时间：
2025-07-10
