A total of 213 PTEN missense variants comprising of 147 VUS, 54 ClinVar Pathogenic and 12 Benign variants were slected for classification utilizing the MD simulations study.
The macromolecular conformational transition between the closed conformation of apo-adenylate kinase from E. coli (EcAdK) to the open conformation was sampled with two methods: (1) dynamic importance
