Loss of VANG-1 but not CAM-1/Ror in the <i>lin-17</i> (Fz) mutant background retains sensitivity to CHW-1 activity.

a compared to lin-17(n671); gfp(RNAi); vang-1(ok1142) b compared to lin-17(n671); gfp(RNAi) c compared to lin-17(n671); chw-1(ok697); gfp(RNAi) d compared to cam-1(gm122); lin-18(e620) e compared to cam-1(gm122); gfp(RNAi); lin-18(e620) f compared to lin-18(e620) § Data previously published [21] Also, loss of CAM-1 but not VANG-1 in the lin-18 (Ryk) background retains sensitivity to CHW-1 activity. In other words, VANG-1 loss abolishes the ability of lin-18 mutant animals to respond to chw-1 mutation or RNAi. Animals were maintained at 23°C and scored by DIC at late L4 stage. n is number of animals scored. Analyses of statistical significance were performed using Fisher’s exact test.