Cooperative JAK-STAT/MAP-kinase/MYC deregulation in Plasmablastic Lymphoma. Cooperative JAK-STAT/MAP-kinase/MYC deregulation in Plasmablastic Lymphoma

Plasmablastic lymphoma is an aggressive B-cell lymphoma with an immunoblastic/large cell morphology anda plasmacytic differentiation. The differential diagnosis with Burkitt lymphoma, plasma cell myeloma and some variants of diffuse large B-cell lymphoma may be challenging due to the overlapping morphological, genetic and immunophenotypic features. Furthermore, the profile of chromosomal alterations is not well known. Overall design: The aim of this study was to perform a complete genetic characterization of PBL. Thirty-four cases were analyzed byFISH, copy number array and targeted next-generation sequencing of 94 B-cell lymphoma related genes.