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Total Synthesis of Lathyranoic Acid A

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https://figshare.com/articles/dataset/Total_Synthesis_of_Lathyranoic_Acid_A/2686393
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资源简介:
The first total synthesis of lathyranoic acid A (1) was accomplished stereoselectively in a linear sequence of 20 steps and an overall yield of 1.4%. This modular synthesis featured a cyclic, stereocontrolled Cu-catalyzed intramolecular cyclopropanation to construct the cis-cyclopropane unit, a Grubbs metathesis to construct the γ-substituted cyclopentenone moiety, and an anion-mediated conjugate addition.
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2011-03-04
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