Cryo-EM structure of Human NLRP3 complex with compound 3
收藏Protein Data Bank Japan2025-03-12 更新2026-04-19 收录
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Cryo-EM structure of Human NLRP3 complex with compound 3 Descriptor: (2P)-2-(4-{[(3R)-1-methylpiperidin-3-yl]amino}-5,6,7,8-tetrahydrophthalazin-1-yl)-5-(trifluoromethyl)phenol, ADENOSINE-5'-TRIPHOSPHATE, NACHT, ... Authors: Mammoliti, O, Carbajo, R.J, Perez-Benito, L, Yu, X, Prieri, M.L.C, Bontempi, L, Embrechts, S, Paesmans, I, Bassi, M, Bhattacharya, A, Roman, S.C, Hoog, S.D, Demin, S, Gijsen, H.J.M, Hache, G, Jacobs, T, Jerhaoui, S, Leenaerts, J, Lutter, F.H, Matico, R, Oehlrich, D, Perrier, M, Ryabchuk, P, Schepens, W, Sharma, S, Somers, M, Suarez, J, Surkyn, M, Opdenbosch, N.V, Verhulst, T, Bottelbergs, A. Deposit date: 2024-12-12 Release date: 2025-02-26 Last modified: 2025-03-12 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Discovery of Potent and Brain-Penetrant Bicyclic NLRP3 Inhibitors with Peripheral and Central In Vivo Activity. J.Med.Chem., 68, 2025
创建时间：
2024-12-12
